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Temocillin in cystic fibrosis: A retrospective pilot study

Kent, Lisa, Bradley, Judy, France, Megan, Doring, Gerd, Carryn, Stephane, Bradbury, Ian, Rendall, Jackie, Jones, Andrew and Elborn, J. Stuart (2008) Temocillin in cystic fibrosis: A retrospective pilot study. Journal of Cystic Fibrosis, 7 (6). pp. 551-554. [Journal article]

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URL: http://www.cysticfibrosisjournal.com/article/S1569-1993(08)00097-0/abstract

DOI: 10.1016/j.jcf.2008.06.005


Background: Temocillin is currently used in the treatment of acute pulmonary exacerbations caused by Burkholderia cepacia complex and multi-resistant Pseudomonas aeruginosa in cystic fibrosis (CF) patients despite little published clinical data. This study assessed if intravenous (IV) antibiotic therapy including temocillin was equivalent to standard combination therapy for an acute exacerbation.MethodsA retrospective, pilot cross-over study. Adult patients attending two CF centres between 1997 and 2006 who had received a course of IV antibiotics including temocillin (TIV) and a further IV course (within ±1 year) which did not include temocillin (NTIV) were included. Outcome measures at the start and end of each IV course were recorded (FEV1%, FVC%).ResultsTwenty six patients had received temocillin. Baseline values of FEV1% predicted were comparable for both groups (TIV: 37(18%), NTIV: 39(20%)). FEV1% increased by 7.12(11.67)% after TIV (p<0.01) and 6.65(7.62)% after NTIV (p<0.01). There was no significant difference between the IV courses in mean %change in lung function TIV versus NTIV (FEV1 0.46% [95%CI: −4.55 to 5.48%]).ConclusionThese data suggest equivalence in the lung function outcome of IV antibiotic therapy includingtemocillin versus standard IV antibiotic therapy.

Item Type:Journal article
Keywords:Temocillin, Burkholderia cepacia complex, Pseudomonas aeruginosa
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Health Sciences
Research Institutes and Groups:Institute of Nursing and Health Research > Centre for Health and Rehabilitation Technologies
ID Code:10120
Deposited By: Professor Judy Bradley
Deposited On:29 Jan 2010 12:43
Last Modified:09 Oct 2013 15:31

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