Ahmadi, S., McCarron, P. A., Donnelly, R. F., Woolfson, A. D. and McKenna, K. (2004) Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study. Experimental dermatology, 13 (7). pp. 445-451. [Journal article]
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Aminolevulinic acid (ALA) is a charged, hydrophilic molecule that penetrates poorly through cellular structures. This property has been implicated in the poor clinical response of non-superficial basal cell carcinomas (BCCs) to photodynamic therapy (PDT). Release of ALA hydrochloride from a 20% w/w formulation was found to be incomplete and that approximately 36.8% of the total dose is released during the application period of 4 h. Using scintillation spectroscopy and a precise tissue sectioning protocol, it was demonstrated that depths of penetration of at least 2 mm from the lesion surface had been reached. Using cumulative stratal ALA concentrations, it was found that 10% of the total applied dose permeated into the lesion. In spite of this, comparisons drawn with photodynamic concentrations used in tissue culture work reported elsewhere revealed that estimations of the ALA concentration at 2 mm were sufficient to elicit a possible therapeutic response. Results from this work question the reasons given for poor outcomes of PDT in nodular BCC based solely on depth as a hindering factor.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science|
Faculty of Life and Health Sciences
|Deposited By:||Professor Paul McCarron|
|Deposited On:||25 Nov 2009 16:45|
|Last Modified:||26 Nov 2012 12:05|
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