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Drug delivery strategies for photodynamic antimicrobial chemotherapy: From benchtop to clinical practice

Cassidy, C. M., Tunney, M. M., McCarron, Paul and Donnelly, R. F. (2009) Drug delivery strategies for photodynamic antimicrobial chemotherapy: From benchtop to clinical practice. Journal of Photochemistry and Photobiology B-Biology, 95 (2). pp. 71-80. [Journal article]

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DOI: 10.1016/j.photobiol.2009.01.005


Light and photosensitizer-mediated killing of many pathogens, termed photodynamic antimicrobial chemotherapy (PACT), has been extensively investigated in vitro. A wide range of organisms from the Gram-positive Staphylococcus aureus to the Gram-negative Pseudomonas aeruginosa have been proven to be susceptible to PACT. Multidrug-resistant strains are just as susceptible to this treatment as their naive counterparts. Both enveloped and non-enveloped viruses have demonstrated susceptibility in vitro, in addition to fungi and protozoa. Significantly, however, no clinical treatments based on PACT are currently licensed. This paper provides a comprehensive review of work carried out to date on delivery of photosensitizers for use in PACT, including topical, intranasal and oral/buccal delivery, as well as targeted delivery. We have also reviewed photo-antimicrobial surfaces. It is hoped that, through a rational approach to formulation design and subsequent success in small-scale clinical trials, more widespread use will be made of PACT in the clinic, to the benefit of patients worldwide. (C) 2009 Elsevier B.V. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:1114
Deposited By: Professor Paul McCarron
Deposited On:21 Oct 2010 14:29
Last Modified:26 Nov 2012 11:47

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