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Effect of folic acid supplementation on mood and serotonin response in healthy males

Williams, E, Stewart-Knox, Barbara J., Bradbury, I, Rowland, I, Pentieva, Kristina, Helander, A and McNulty, H (2005) Effect of folic acid supplementation on mood and serotonin response in healthy males. British Journal of Nutrition, 94 (4). pp. 602-608. [Journal article]

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DOI: 10.1079/BJN20051501


Evidence suggests that low folate status may be detrimental to mood and associated with depleted cerebrospinal fluid levels of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT). A placebo-controlled trial was carried out to determine the effect of folic acid supplementation (100 mu g for 6 weeks followed by 200 mu g for a further 6 weeks) upon subjective mood (Positive and Negative Affect Schedule) and biochemical markers of mood (5-HT) in healthy males (n 23). Blood samples were obtained at baseline (week 0) and during the intervention at week 6 and week 12. Subjective mood assessments were obtained at week 0 and week 12. The results showed an increase in serum and erythrocyte folate concentrations (P=0.02 and P=0.003, respectively) and a corresponding decrease in plasma homocysteine (P=0.015) in response to the folic acid intervention. Neither subjective mood nor 5-HT levels, however, were significantly altered in response to the change in folate status. Folic acid given at physiological doses did not appear to improve the mood of healthy folate-replete individuals over a 12-week period. Further research is needed to address the effect of folic acid supplementation or of longer duration or increased dose, particularly in the face of sub-optimal folate status.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:11363
Deposited By: Dr Barbara Stewart-Knox
Deposited On:10 Feb 2010 15:09
Last Modified:09 Dec 2015 10:43

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