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Anti-adherent and antifungal activities of surfactant-coated poly (ethylcyanoacrylate) nanoparticles

McCarron, P. A., Donnelly, R. F., Marouf, W. and Calvert, D. E. (2007) Anti-adherent and antifungal activities of surfactant-coated poly (ethylcyanoacrylate) nanoparticles. International journal of pharmaceutics, 340 (1-2). pp. 182-190. [Journal article]

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DOI: http://dx.doi.org/10.1016/j.ijpharm.2007.03.029

Abstract

Application of non-drug-loaded poly(ethylcyanoacrylate) nanoparticles (NP) to buccal epithelial cells (BEC) imparted both anti-adherent and antifungal effects. NP prepared using emulsion polymerisation and stabilised using cationic, anionic and non-ionic surfactants decreased Candida albicans blastospore adhesion, an effect attributable to the peripheral coating of surfactant. Cetrimide and Pluronic (R) P 123 were shown to be most effective, producing mean percentage reductions in blastospore adherence of 52.7 and 37.0, respectively. Resultant zeta potential matched the polarity of the surfactant, with those stabilised using cetrimide being especially positive (+31.3 mV). Preparation using anionic surfactants was shown to be problematic, with low yield and wide particle size distribution. Evaluation of the antifungal effect of the peripheral coat was evaluated using zones of inhibition and viable counts assays. The former test revealed poor surfactant diffusion through agar, but did show evidence of limited kill. However, the latter method showed that cationic surfactants associated with NP produced high levels of kill, in contrast to those coated with anionic surfactants, where kill was not evident. Non-ionic surfactant-coated NP produced intermediate kill rates. Results demonstrate that surfactant-coated NP, particularly the cationic types, form the possible basis of a prophylactic formulation that primes the candidal target (BEC) against fungal adhesion and infection. (c) 2007 Elsevier B.V. All rights reserved.

Item Type:Journal article
Keywords:Candida albicans; Blastospores; Poly(ethylcyanoacrylate) nanoparticles; Adherence; Antifungal
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:1155
Deposited By: Professor Paul McCarron
Deposited On:17 May 2017 09:47
Last Modified:17 May 2017 09:48

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