Woolfson, A. D., McCafferty, D. F., McCarron, P. A. and Price, J. H. (1994) Liquid Scintillation Spectrometry of 5-Fluorouracil in Cervical Tissue Following In-Vitro Surface Application of a Bioadhesive Cervical Patch. Pharmaceutical research, 11 (9). pp. 1315-1319. [Journal article]
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The potential use of bioadhesive technology for the treatment of cervical intraepithelial neoplasia was investigated. A cervical patch was designed containing 5-fluorouracil in a bioadhesive matrix and polyvinyl chloride as the backing layer. The concentration of 5-fluorouracil at specified tissue depths from the cervical surface was determined in vitro in relation to the ability of the drug to reach precancerous foci in cervical crypts up to 4 mm below the tissue surface. Thus, tissue was exposed to drug-loaded patches spiked with 5-fluorouracil-6-H-3 and subsequently sectioned to obtain tissue slices at different depths. The concentration of 5-fluorouracil was determined by liquid scintillation spectrometry. Drug penetration into cervical tissue exceeded a depth of 5.5 mm. Furthermore, the concentration in the tissue depended on the drug loading in the patch. Patches containing 10 and 20 mg of 5-fluorouracil produced a linear drug gradient that was established after a 4 hour application of the patch and persisted over 24 hours. However, patches containing 3.5 mg of 5-fluorouracil displayed signs of drug exhaustion after 24 hours. The penetration characteristics of 5-fluorouracil through cervical tissue using the cervical patch delivery system were sufficiently favourable to warrant further clinical investigations.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science|
Faculty of Life and Health Sciences
|Deposited By:||Professor Paul McCarron|
|Deposited On:||25 Nov 2009 16:42|
|Last Modified:||29 Nov 2012 11:51|
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