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Molecular anchors - mimicking metabolic processes in thiol analysis

Smith, RB, Canton, C, Lawrence, NS, Livingstone, C and Davis, J (2006) Molecular anchors - mimicking metabolic processes in thiol analysis. NEW JOURNAL OF CHEMISTRY, 30 (12). pp. 1718-1724. [Journal article]

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DOI: 10.1039/b611471g


The interaction between various novel naphthoquinones and glutathione was explored using a variety of electrochemical techniques. An adamantane derivatised quinone was found to adsorb strongly to carbon surfaces providing a robust film possessing a distinct and consistent voltammetric profile which is markedly different from solution based species. The anodic peak process was found to respond to increasing additions of glutathione and the analytical merits have been assessed. In contrast to conventional thiol-quinone electrochemistry, the detection pathway involves the solubilisation and removal of the hydrophobic quinone derivative through conjugation with glutathione. The peak potential (+0.2 V vs. Ag/AgCl) is such that an unambiguous response to glutathione can be achieved in the presence of a significant excess (1 mM) of common physiological components.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14325
Deposited By: Professor James Davis
Deposited On:01 Jul 2010 08:13
Last Modified:18 Aug 2011 10:19

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