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Development of a disposable potentiometric sensor for the near patient testing of plasma thiol concentrations

Gracheva, S, Livingstone, C and Davis, J (2004) Development of a disposable potentiometric sensor for the near patient testing of plasma thiol concentrations. ANALYTICAL CHEMISTRY, 76 (13). pp. 3833-3836. [Journal article]

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DOI: 10.1021/ac035308y

Abstract

The reaction of naphthoquinone with physiological thiols has been investigated as the basis of a NPT strategy for the measurement of the latter. Screen-printed carbon electrode assemblies provide an inexpensive and inherently disposable platform for the detection methodology. The key analytical parameters underpinning the selective and sensitive (0.4 uM - 1 mM) determination of reduced thiol have been assessed, and the clinical efficacy of the approach has been demonstrated through its application to the analysis of human plasma. The results have been corroborated using standard techniques, and the routes through which the system can be adopted within mainstream biomedical environments are highlighted.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14346
Deposited By: Professor James Davis
Deposited On:01 Jul 2010 08:36
Last Modified:18 Aug 2011 10:19

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