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Electrochemical determination of thiols: A perspective

White, PC, Lawrence, NS, Davis, J and Compton, RG (2002) Electrochemical determination of thiols: A perspective. ELECTROANALYSIS, 14 (2). pp. 89-98. [Journal article]

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Monitoring thiol concentrations within physiological fluids has risen to considerable importance within the biomedical communities as our appreciation of the various roles that these compounds can perform has increased. Their utilization as biomarkers for numerous clinical conditions has prompted considerable interest in the development of analytical protocols that enable speedy measurements to be made. As such, a large number of procedures have arisen. This perspective highlights the contexts where physiological thiol measurements are required and describes the basis of many of the current electrochemical approaches to their determination. The collation of information from a broad range of sources covering the major electrochemical approaches (direct, indirect, and post column/capillary detection) has been achieved and the salient points of each technique critically appraised. The various characteristics and limitations of the systems are compared and contrasted with the analytical parameters (matrix, methodology, detection limit etc) from each major grouping tabulated to aid direct comparison.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14364
Deposited By: Professor James Davis
Deposited On:01 Jul 2010 08:47
Last Modified:18 Aug 2011 10:19

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