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Thyroxine replacement in an animal model of congenital hypothyroidism

Reid, Rosemary E., Kim, Eun-Mee, Page, Deaglan, O'Mara, Shane M. and O'Hare, Eugene (2007) Thyroxine replacement in an animal model of congenital hypothyroidism. PHYSIOLOGY & BEHAVIOR, 91 (2-3). pp. 299-303. [Journal article]

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DOI: 10.1016/j.physbeh.2007.03.005


This study examined the effects of thyroxine (T-4) treatment on spatial learning and memory in congenitally hypothyroid (CH) rats. Forty CH male offspring of methimazole-treated dams were randomly divided into three groups: no T-4 (vehicle) treatment (n= 12), T-4 treatment commencing on postnatal day (P-) 7 (n = 14), and T-4 treatment commencing on P-21 (n = 14). Normal male rats were used as a control group (it = 14). T4 was administered daily (sc, 0.02 mu g/g) to the treatment groups for 30 days. A water-maze was used to assess behaviour at 42, 70 and 98 days of age. T-4 treatment beginning at P-7 improved learning and memory associated with CH at 70 and 98 days of age but T-4 treatment beginning at P-21 did not improve CH-impaired learning and memory. (C) 2007 Elsevier Inc. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute > Behavioural Neuroscience and Behaviour Analysis
Psychology Research Institute
ID Code:1629
Deposited By: Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:27
Last Modified:13 Mar 2012 16:34

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