McDaid, DG, Kim, Eun-Mee, Reid, RE, Leslie, Julian, Cleary, J and O'Hare, E (2005) Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated A beta((1-42)) injections. BEHAVIOURAL PHARMACOLOGY, 16 (4). pp. 237-242. [Journal article]
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There is evidence that oxidative stress may play a role in the neuropathology of Alzheimer's disease (AD). This study used an aggregated beta-amyloid (A beta) injection model of AD in the rat, and a recycling conjunctive schedule of food reinforcement to examine the effects of bilateral intrahippocampal injections of aggregated A beta((1-42)) (5.0 mu l/side) on temporal discrimination, and the efficacy of the antioxidant alpha-tocopherol (150 mg/kg daily p.o.) in alleviating these effects. The results indicated that bilateral intrahippocampal injections of aggregated A beta((1-42)) detrimentally affected temporal discrimination from five-day block 31-35 post-injections until the end of the study (90 days post-injections). Daily treatment with alpha-tocopherol improved temporal discrimination under the recycling conjunctive schedule following aggregated A beta((1-42)) injections from the five-day block 61-65 days until the end of the study.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Psychology
|Research Institutes and Groups:||Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis|
Psychology Research Institute
|Deposited By:||Mrs Fiona Harkin|
|Deposited On:||23 Dec 2009 09:28|
|Last Modified:||13 Mar 2012 16:33|
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