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Granisetron attenuates exercise-induced conditioned taste aversion in the rat

Eccles, S, Kim, Eun-Mee and O'Hare, E (2005) Granisetron attenuates exercise-induced conditioned taste aversion in the rat. APPETITE, 44 (3). pp. 325-328. [Journal article]

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DOI: 10.1016/j.appet.2005.02.001


A conditioned taste aversion (CTA) paradigm was used in the present study to investigate whether CTA produced by exercise could be attenuated by the 5-HT3 receptor antagonist granisetron. Male Sprague-Dawley rats were randomly allocated to one of four groups (Ns = 6) and were exposed to salty (0.128 M sodium chloride) or sour (0.00138 M citric acid) solutions. Subjects were injected with either saline solution (1.0 ml, 0.9 %) or granisetron (0.5 mg/kg, IP) and were exposed to 30 min of forced wheel running exercise (70 revolutions/30 min) 10 min after injection. Exercise induced CTA to both the salty (3.7 ml intake) and sour-flaroured (3.1 ml intake) solutions as compared with no exercise (intake 14.0 and 13.7 ml), and administration of granisetron significantly attenuated the exercise-induced CTA to the salty- and sour-flavoured solutions. (c) 2005 Elsevier Ltd. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute > Behavioural Neuroscience and Behaviour Analysis
Psychology Research Institute
ID Code:1634
Deposited By: Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:28
Last Modified:13 Mar 2012 16:34

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