Kim, Eun-Mee, Grace, MK, O'Hare, E, Billington, CJ and Levine, AS (2002) Injection of alpha-MSH, but not beta-endorphin, into the PVN decreases POMC gene expression in the ARC. NEUROREPORT, 13 (4). pp. 497-500. [Journal article]
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beta-Endorphin (beta-END) and alpha-melanocyte stimulating hormone (alpha-MSH), neuropeptides derived from proopiomelanocortin (POMC), have opposite effects on eating behavior. We injected rats with alpha-MSH (0.6 nmol) or beta-END (1 nmol) into the PVN (three times in a 26 h period). These doses of alpha-MSH and beta-END decreased and increased feeding respectively. Following alpha-MSH administration into the PVN, m RNA levels of POMC decreased by 17%, whereas there was no significant change in gene expression of either proDynorphin or proEnkephalin. PVN injection of beta-END failed to alter gene expression of POMC, proDynorphin or proEnkephalin. These data suggest that a feedback pathway exists between the PVN and ARC for alpha-MSH and POMC, but not for beta-END and POMC.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Psychology
|Research Institutes and Groups:||Psychology Research Institute > Behavioural Neuroscience and Behaviour Analysis|
Psychology Research Institute
|Deposited By:||Mrs Fiona Harkin|
|Deposited On:||23 Dec 2009 09:29|
|Last Modified:||13 Mar 2012 16:34|
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