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Effects of drugs that potentiate GABA on extinction of positively-reinforced operant behaviour

Leslie, Julian, Shaw, David, McCabe, C, Reynolds, DS and Dawson, GR (2004) Effects of drugs that potentiate GABA on extinction of positively-reinforced operant behaviour. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 28 (3). pp. 229-238. [Journal article]

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DOI: 10.1016/j.neubiorev.2004.01.003


Extinction following positively reinforced operant conditioning reduces response frequency, at least in part through the aversive or frustrative effects of non-reinforcement. According to J.A. Gray's theory, non-reinforcement activates the behavioural inhibition system which in turn causes anxiety. As predicted, anxiolytic drugs including benzodiazepines affect the operant extinction process. Recent studies have shown that reducing GABA-mediated neurotransmission retards extinction of aversive conditioning. We have shown in a series of studies that anxiolytic compounds that potentiate GABA facilitate extinction of positively reinforced fixed-ratio operant behaviour in C57B1/6 male mice. This effect does not occur in the early stages of extinction, nor is it dependent on cumulative effects of the compound administered. Potentiation of GABA at later stages has the effect of increasing sensitivity to the extinction contingency and facilitates the inhibition of the behaviour that is no longer required. The GABAergic hypnotic, zolpidem, has the same selective effects on operant extinction in this procedure. The effects of zolpidem are not due to sedative action. There is evidence across our series of experiments that different GABA-A subtype receptors are involved in extinction facilitation and anxiolysis. Consequently, this procedure may not be an appropriate model for anxiolytic drug action, but it may be a useful technique for analysing the neural bases of extinction and designing therapeutic interventions in humans where failure to extinguish inappropriate behaviours can lead to pathological conditions such as post-traumatic stress disorder. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute > Behavioural Neuroscience and Behaviour Analysis
Psychology Research Institute
ID Code:1651
Deposited By: Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:31
Last Modified:19 Sep 2017 14:08

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