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Effects of chlordiazepoxide on extinction and re-acquisition of operant behaviour in mice

Shaw, David, Dawson, GR, Reynolds, DS, McCabe, C and Leslie, Julian (2004) Effects of chlordiazepoxide on extinction and re-acquisition of operant behaviour in mice. BEHAVIOURAL PHARMACOLOGY, 15 (3). pp. 225-232. [Journal article]

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DOI: 10.1097/01.fbp.0000132914.11693.c7


Relatively little is known about the role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in extinction of appetitively motivated tasks. The benzodiazepine (BZ) chlordiazepoxide (CDP) was administered during extinction and re-acquisition of lever pressing by mice following food reinforced discrete-trial fixed-ratio 5 (FR-5) training. Typical FR behaviour was established during baseline training and persisted for several extinction sessions. There were 15 extinction sessions in all, followed by six re-acquisition sessions where food reinforcement was re-introduced. In a 2 x 2 x 2 between-group design, CDP (15 mg/kg) or vehicle injections were given prior to either the last two food reinforcement sessions and the first 10 extinction sessions, or the final five extinction sessions, or the six re-acquisition sessions. Initially CDP had no effect on the rate of extinction, but after several extinction sessions it significantly facilitated it. Surprisingly, if CDP was administered only after several sessions of extinction, it immediately produced facilitation. Thus the delayed effects of CDP are not due to drug accumulation. These data suggest that some neural change must occur before CDP can affect extinction processes. In re-acquisition sessions, CDP facilitated the reinstatement of food-reinforced lever pressing. Implications for neural and behavioural accounts of operant extinction are discussed.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute > Behavioural Neuroscience and Behaviour Analysis
Psychology Research Institute
ID Code:1652
Deposited By: Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:32
Last Modified:19 Sep 2017 14:09

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