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Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches

Morrow, Desmond I. J., McCarron, P. A., Woolfson, A. David, Juzenas, Petras, Juzeniene, Asta, Iani, Vladimir, Moan, Johan and Donnelly, Ryan F. (2010) Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches. JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 (6, Sp.). pp. 685-695. [Journal article]

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DOI: 10.1211/jpp/62.06.0004


Objectives The inclusion 01 chemical penetration enhancers in a novel patch-based system for the delivery of 5-aminolevulinic acid (ALA) was examined in vitro and in vivo. Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions. such as nodular basal cell carcinomas. Methods Several chemical permeation enhancers (dimethylsulfoxide, Labrafac CC. Labrafac PG and Labrafil M1944CS) were incorporated into bioadhesive patches tailored to deliver 19 mg ALA/cm(2). Key findings In-vitro depth penetration studies into excised porcine skin showed that high concentrations of ALA (>9 mu mol/cm(3)) could be delivered to a depth of 1.875 mm. However, inclusion of permeation enhancers did not significantly increase ALA delivery, relative to the control (P > 0.05). In-vivo studies were in strong agreement with in-vitro results, with formulations containing chemical enhancers showing no improvement in delivery compared with the control. Conclusions The patches designed in this work are suited to defineable ALA delivery without the need to immobilise patients for up to 6 h, as IS common with the cream-under-occlusion approach. Overall, permeation enhancers were not found to markedly enhance the topical delivery of ALA. 11 chemical penetration enhancers may have a greater effect on the delivery of more lipophilic ALA prodrugs, which are thought to primarily permeate the stratum corneum via the intercellular pathway.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:17124
Deposited By: Professor Paul McCarron
Deposited On:17 Feb 2011 14:56
Last Modified:26 Nov 2012 11:44

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