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Folate status and mood: is there a relationship?

Williams, Emma, Stewart-Knox, Barbara, McConville, Christopher, Bradbury, Ian, Armstrong, Nicola C. and McNulty, Helene (2008) Folate status and mood: is there a relationship? PUBLIC HEALTH NUTRITION, 11 (2). pp. 118-123. [Journal article]

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DOI: 10.1017/S1368980007000031


Objective: To explore the relationship between subjective mood, folate status and homocysteine in healthy individuals. Design: Subjective mood assessments were completed twice daily over the course of one week using the Positive and Negative Affect Scale (PANAS). The PANAS is a validated scale which considers mood state on two distinct continua, one reflecting positive mood and the other negative mood, each requiring response to 10 adjectives on a Likert scale. A blood sample was taken on one occasion at the start of the week during which subjective mood was assessed and analysed for red-blood-cell (RBC) folate, serum folate and plasma homocysteine concentrations. Subjects: Male volunteers aged 19-47 years (n = 58) were recruited from local industries. Results: High concentrations of RBC folate were associated with less variability (lower standard deviation) in negative mood (P= 0.023). Subjective mood, however, was not related to serum folate or homocysteine. Conclusions: This Study appears to be the first to uncover an association between long-term folate status and subjective mood (employing the PANAS) in healthy mates. More research is needed to further explore the relationship between nutritional status and mood.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
Psychology Research Institute
Psychology Research Institute > Health, Education and Well-being
ID Code:1714
Deposited By: Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:44
Last Modified:16 Dec 2013 15:15

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