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G-Quadruplex Nucleic Acids

Eritja, R, Mergny, J.L., Montesarchio, D, Spindler, L and Webba da Silva, Mateus (2010) G-Quadruplex Nucleic Acids. Journal of Nucleic Acids, 2010 (Articl). [Journal article]

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DOI: 10.4061/2010/147650


G-quadruplexes are a family of four-stranded structuresstabilized by guanine quartets, in which four planar guaninesestablish a cyclic array of hydrogen bonds. They are ofspecial interest due to the increasing evidence for theirformation in vivo and their possible implication in biology,especially at telomeres and as contributors to gene regulation.Moreover, G-quadruplexes are also formed as a result ofself-assembling processes of guanosine derivatives, yieldingseveral interesting motifs such as G-ribbons and G-wireswhich have peculiar electrical conductivity properties thatare being explored as molecular wires.This special issue is initiated with two articles discussingthe self-assembling properties of guanosine derivatives whichdescribe the basic principles of G-quadruplex formation. Thefirst article by Neviani et al. analyzes the presence of severallevels of organization of guanosine derivatives carryingone or two lipophilic units as observed by light scatteringtechniques and transmission electron microscopy (TEM)experiments. The second article by Mariani et al. describesa study on quadruplex formation of 2 -deoxyguanosinemonophosphate by small-angle X-ray scattering techniques.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Genomic Medicine
ID Code:18288
Deposited By: Dr Mateus Webba da Silva
Deposited On:03 May 2011 10:31
Last Modified:10 May 2017 10:03

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