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Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri

Zhou, Jianwu, Mcclean, Stephen, Thompson, Alan, Zhang, Yang, Shaw, Chris, Rao, Pingfan and Bjourson, AJ (2006) Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. PEPTIDES, 27 (12). pp. 3077-3084. [Journal article]

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DOI: 10.1016/j.peptides.2006.08.007


Linear, amphipathic and cationic antimicrobial peptides have been previously reported from a wide range of amphibian species especially frogs of the genus Rana. Such antimicrobial peptides are attracting increasing attention in pharmacological applications because they mainly act by permeabilizing and disrupting the target cell or virion membranes with a low degree of resistance. The Guenther's frog, Hylarana guentheri, is a Chinese frog of the genus Rana that is widely distributed in Southern China. It is commonly the dominant amphibian species even where the amphibian population is declining. In this study, we describe the isolation, purification, structural and biological characterization of five novel peptides from H. guentheri frog skin secretions that possess antimicrobial activity, including brevinin-2GHa, brevinin-2GHb, brevinin-2GHc, temporin-GH and a novel antimicrobial peptide named guentherin. The cDNAs encoding two novel members of the brevinin-2 family, brevinin-2GHb and brevinin-2GHc were also subsequently cloned and sequenced. (c) 2006 Elsevier Inc. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Stratified Medicine
Biomedical Sciences Research Institute > Diabetes
ID Code:1928
Deposited By: Mrs Caroline Adams
Deposited On:30 Nov 2009 09:25
Last Modified:24 Jun 2015 10:49

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