Beirne, Raymond, Hogg, Ruth, Stevenson, Michael, Anderson, Roger and Chakravarthy, Usha (2008) Visual function, age-related maculopathy stage and the subsequent development of age-related macular degeneration. In: UNSPECIFIED. UNSPECIFIED. Vol 49 (5) [Conference contribution]
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Purpose: To investigate the relationship between baseline psychophysical measures ofvisual function in age-related maculopathy (ARM) and the subsequent development ofadvanced visual loss from age-related macular degeneration.Methods: 36 participants (aged 52-85yrs) with early ARM and good acuity (≤ 0.3 logMAR) inthe study eye and advanced AMD in the fellow eye underwent a battery of psychophysicaltests at baseline examination (logMAR acuity, Pelli-Robson contrast sensitivity, photopicand scotopic interferometric acuity, achromatic and short-wavelength-sensitive (SWS)resolution acuity). Stereoscopic colour fundus photographs were graded using theWisconsin Age-Related Maculopathy Grading System (WARMGS) and features of ARMwere combined to assign a severity stage from 0 to 5 using the methods described bythe Rotterdam Eye Study. Participants clinical records were examined for a period ofup to 5 years from baseline, with participants being divided into two groups based onwhether or not the study eye lost a significant amount of visual acuity (greater than 3lines of logMAR acuity) in this follow-up period.Results: 8 participants suffered a significant drop in visual acuity during follow-up, while26 participants did not. There was no significant difference in age (M=73.4 vs 71.9yrs;p=0.63) or follow-up time (M=34.2 vs 28.5mths; p=0.34) between these two groups.Achromatic and SWS resolution acuity were both significantly reduced at baseline inthose subjects who developed a significant loss in visual acuity compared to those whodid not (p<0.05). There was no significant difference in any of the other visual functionmeasures between the two groups. ARM stage at baseline was the strongest predictorof disease progression, with a significant difference in the baseline ARM stage betweenthose who lost a significant amount of visual acuity over this follow-up period and thosewho did not (Mann-Whitney U test, p=0.03).Conclusions: This study has shown that although advancing ARM stage (stages 4, 5)was the strongest predictor of subsequent visual acuity loss in this group of participants,measures of achromatic and SWS resolution acuity in ARM have the potential to identifythose most at risk of subsequently developing significant visual loss due to AMD. Largerlongitudinal studies are required to fully investigate the relationships between ARMstage, visual function and the development of significant visual loss and end-stagedisease.
|Item Type:||Conference contribution (UNSPECIFIED)|
|Faculties and Schools:||Faculty of Life and Health Sciences > School of Biomedical Sciences|
Faculty of Life and Health Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Vision
|Deposited By:||Dr Raymond Beirne|
|Deposited On:||28 Feb 2012 11:02|
|Last Modified:||10 May 2013 08:37|
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