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Brain Tumours: Pre-clinical Assessment of Targeted, SiteSpecific Therapy Exploiting Ultrasound and CancerChemotherapeutic Drugs

McHale, Anthony and Nomikou, N (2012) Brain Tumours: Pre-clinical Assessment of Targeted, SiteSpecific Therapy Exploiting Ultrasound and CancerChemotherapeutic Drugs. In: Tumors of the Central Nervous System, Volume 4. Springer, pp. 313-322. ISBN 978-94-007-1706-0 [Book section]

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URL: http://dx.doi.org/10.1007/978-94-007-1706-0_32

DOI: 10.1007/978-94-007-1706-0_32

Abstract

Although recent advances in developingdrug carriers and targeting systems to facilitate sitedirected,cancer chemotherapy-based treatment modalitiesfor solid tumours in general have indicated verysignificant patient benefit, tumours occurring in thebrain have presented significant challenges. The purposeof this chapter will be to review existing therapeuticapplications of transcranial ultrasound and toexamine current experimental approaches based on theuse of ultrasound to non-invasively enhance the actionof cancer chemotherapeutics in a site-specific manner.Benefits afforded by such therapeutic strategies in thetreatment of localised intracranial solid tumours willbe highlighted.

Item Type:Book section
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:21292
Deposited By: Professor Anthony McHale
Deposited On:05 Mar 2012 11:21
Last Modified:29 Nov 2012 12:03

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