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METHOTREXATE-LOADED, PHOTOSENSITIZED ERYTHROCYTES - A PHOTO-ACTIVATABLE CARRIER/DELIVERY SYSTEM FOR USE IN CANCER-THERAPY

FLYNN, G, MCHALE, L and MCHALE, AP (1994) METHOTREXATE-LOADED, PHOTOSENSITIZED ERYTHROCYTES - A PHOTO-ACTIVATABLE CARRIER/DELIVERY SYSTEM FOR USE IN CANCER-THERAPY. CANCER LETTERS, 82 (2). pp. 225-229. [Journal article]

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DOI: 10.1016/0304-3835(94)90016-7

Abstract

With a view towards the design of a system incorporating both the use of chemotherapeutics and photodynamic therapy for use in cancer treatment modalities, erythrocytes have been loaded with methotrexate and subsequently photosensitized by exposure to hematoporphyrin derivative. Loading of methotrexate into erythrocytes has been optimized by examining variations in electroporation conditions. Maximum loading indices observed were in the region of 64%. In order to obtain rapid pre-defined release of chemotherapeutic from the system, the erythrocytes were photosensitized. Light-dependent release of methotrexate from the system was examined. In addition, studies measuring the cytotoxic effects of light-activated release from the system using Hela cells as a target, suggested that decreases in cell viability following exposure to light resulted from the combined effects of chemotherapy and photoradiation therapy. Potential applications and advantages associated with this novel system are discussed.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:21513
Deposited By: Professor Anthony McHale
Deposited On:28 Mar 2012 15:15
Last Modified:04 Dec 2012 12:00

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