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The Influence of Solvent Processing on Polyester Bioabsorable Polymers

Dixon, D and Manson, J (2012) The Influence of Solvent Processing on Polyester Bioabsorable Polymers. Journal of Biomaterials Applications, 26 (5). pp. 623-634. [Journal article]

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URL: http://jba.sagepub.com/content/early/2010/07/15/0885328210376997.abstract

DOI: 10.1177/0885328210376997

Abstract

Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lactic-co-glycolic acid) (PLGA) produced by using chloroform, dichloromethane, and acetone. The results demonstrate that solvent choice and PLGA molecular weight are critical factors in terms of solvent removal rate and maintaining sample integrity, respectively. The protocols widely employed result in high levels of residual solvent and a new protocol is presented together with solutions to commonly encountered problems.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:22768
Deposited By: Dr Dorian Dixon
Deposited On:09 Jul 2012 15:21
Last Modified:09 Dec 2015 11:05

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