Morrow, Ryan J, Woolfson, A David, Donnelly, Louise, Curran, Rhonda M, Andrews, Gavin P, Katinger, Dietmar and Malcolm, R Karl (2011) Sustained release of proteins from a modified vaginal ring device. European Journal of Pharmaceutics and Biopharmaceutics, 77 . pp. 3-10. [Journal article]
- Accepted Version
Indefinitely restricted to Repository staff only.
A new vaginal ring technology, the insert vaginal ring (InVR), is presented. The InVR overcomes the current shortfall of conventional vaginal rings (VRs) that are generally ineffectual for the delivery of hydrophilic and/or macromolecular actives, including peptides, proteins and antibodies, due to their poor permeation characteristics in the hydrophobic polymeric elastomers from which VRs are usually fabricated. Release of the model protein BSA from a variety of insert matrices for the InVR is demonstrated, including modified silicone rods, directly compressed tablets and lyophilised gels, which collectively provided controlled release profiles from several hours to beyond 4 weeks. Furthermore, the InVR was shown to deliver over 1 mg of the monoclonal antibody 2F5 from a single device, offering a potential means of protecting women against the transmission of HIV.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences > School of Nursing|
Faculty of Life and Health Sciences
|Research Institutes and Groups:||Institute of Nursing and Health Research|
Institute of Nursing and Health Research > Centre for Maternal, Fetal and Infant Research
|Deposited By:||Dr Rhonda Curran|
|Deposited On:||28 Aug 2012 13:56|
|Last Modified:||28 Aug 2012 13:56|
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