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Development of liposome-based freeze-dried rods for vaginalvaccine delivery against HIV-1

Gupta, Prem N, Pattani, Aditya, Malcolm, R Karl, Curran, Rhonda M and Andrews, Gavin P (2010) Development of liposome-based freeze-dried rods for vaginalvaccine delivery against HIV-1. Journal of Controlled Release, 148 . e108-e110. [Journal article]

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URL: http://ac.els-cdn.com/S0168365910005638/1-s2.0-S0168365910005638-main.pdf?_tid=84d29fb0-f034-11e1-b70a-00000aacb35f&acdnat=1346064595_b328976b70246d6453fcd4a8be0660b9

DOI: 10.1016/j.jconrel.2010.07.080

Abstract

The present investigation dealswith development and characterization of the liposomes-based freeze-dried rods for the vaginal delivery of gp140 antigen in mice. Positively charged, negatively charged and neutral liposomes were prepared and characterized for various parameters e.g. morphology, size, polydispersity index, zeta potential and antigen encapsulation efficiency. To further improve the efficacy of vaccine delivery, antigen encapsulated liposomes were formulated as polymer gel-based freeze-dried rods,which were then characterized for moisture content. The redispersibility of the liposomes-based freezedried rods was determined in simulated vaginal fluid and liposome gel was investigated for mucoadhesion. The developed liposome-based freeze-dried rods systems could offer potential as stable and practical dosage form for the mucosal immunization against HIV-1 infection.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Nursing
Faculty of Life and Health Sciences
Research Institutes and Groups:Institute of Nursing and Health Research
Institute of Nursing and Health Research > Maternal, Fetal and Infant Research
ID Code:23192
Deposited By: Dr Rhonda Curran
Deposited On:04 Sep 2012 13:46
Last Modified:04 Sep 2012 13:46

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