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Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelopeprotein CN54gp140 within novel rheologically structured vehicles elicitsspecific immune responses

Curran, Rhonda M, Donnelly, Louise, Morrow, Ryan J, Fraser, Carole, Andrews, Gavin P, Cranage, Martin, Malcolm , R Karl, Shattock, Robin J and Woolfson, A David (2009) Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelopeprotein CN54gp140 within novel rheologically structured vehicles elicitsspecific immune responses. Vaccine, 27 . pp. 6791-6798. [Journal article]

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URL: http://ac.els-cdn.com/S0264410X09012547/1-s2.0-S0264410X09012547-main.pdf?_tid=d687ea04-f061-11e1-88eb-00000aacb35f&acdnat=1346084060_b2e760fcfbc37d998f554f2f2a480e1a

DOI: 10.1016/j.vaccine.2009.08.088

Abstract

Rheologically structured vehicle (RSV) gels were developed as delivery systems for vaginal mucosal vaccination with an HIV-1 envelope glycoprotein (CN54gp140). RSVs comprised a mucoadhesive matrixforming and vaginal fluid absorbing polymer. The mucoadhesive and rheological properties of the RSVs were evaluated in vitro, and the distribution, antigenicity and release of CN54gp140 were analysed by ELISA. CN54gp140 was uniformly distributed within the RSVs and continuously released in vitro in an antigenically intact form over 24 h. Vaginal administration to rabbits induced specific serum IgG, and IgG and IgA in genital tract secretions. The RSVs are a viable delivery modality for vaginal immunization.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Nursing
Faculty of Life and Health Sciences
Research Institutes and Groups:Institute of Nursing and Health Research > Maternal, Fetal and Infant Research
ID Code:23196
Deposited By: Dr Rhonda Curran
Deposited On:03 Oct 2012 10:24
Last Modified:03 Oct 2012 10:24

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