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Proteomic analysis of recurrent joint inflammation in juvenile idiopathic arthritis.

Gibson, David (2006) Proteomic analysis of recurrent joint inflammation in juvenile idiopathic arthritis. Journal of Proteome Research, 5 (8). pp. 1988-1995. [Journal article]

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URL: http://pubs.acs.org/doi/abs/10.1021/pr060129t

Abstract

The synovial fluid proteome in juvenile idiopathic arthritis was investigated to isolate joint-specific biomarkers that are expressed in patients displaying recurrent joint inflammation. To identify the synovial specific proteome, matched synovial fluid and plasma samples were subjected to protein separation by 2-dimension electrophoresis (2DE). Forty-three protein spots, overexpressed in the joint, were identified. Synovial fluids from children with single-event knee joint inflammation were then compared with a group with recurrent knee disease. Nine synovial specific proteins were significantly differentially expressed in the recurrent group. Proteolytic fragments of collagen X, fibrin beta-chain, and T-cell receptor alpha-region have been identified among this protein cluster. Putative biomarkers, overexpressed in the joint and differentially expressed in children with recurrent joint inflammation, have been identified. These proteins may play a significant role determining the pathological state within the chronically inflamed joint and influence disease progression in JIA. This is the first study of the synovial proteome in children.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Stratified Medicine
ID Code:24627
Deposited By: Dr David Gibson
Deposited On:21 Jan 2013 12:51
Last Modified:09 Dec 2015 11:10

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