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Water soluble quantum dots as hydrophilic carriers and two-photon excitedenergy donors in photodynamic therapy

Fowley, Colin, Nomikou, Nikolitsa, McHale, Anthony P., McCarron, Paul, McCaughan, Bridgeen and Callan, John (2012) Water soluble quantum dots as hydrophilic carriers and two-photon excitedenergy donors in photodynamic therapy. Journal of Materials Chemistry, 22 (13). pp. 6456-6462. [Journal article]

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DOI: 10.1039/c2jm00096b

Abstract

In search of strategies to develop deeply penetrating agents for use in Photodynamic Therapy (PDT),we have devised a Quantum Dot-Rose Bengal conjugate that is effective at producing singlet oxygenupon two-photon irradiation. The CdSe/ZnS Quantum Dot, with its high two photon absorption crosssection, serves as a two-photon absorbing antenna and transfers its excited state energy to the attachedphotosensitiser which engages with molecular oxygen to produce cytotoxic singlet oxygen. Thus, wewere able to excite the photosensitiser indirectly, which has an absorption maximum of 565 nm, withtwo-photon irradiation at 800 nm. Given the tissue penetration depth of 800 nm light is at least fourtimes greater than 565 nm light, this offers the opportunity to access much deeper-seated tumours thanis currently possible with pharmaceutically approved photosensitisers. Furthermore, the attachment ofthe photosensitiser to the hydrophilic quantum dot improved the aqueous solubility of thephotosensitiser by 48 fold, thus overcoming another limitation of currently used photosensitisers, thatof poor aqueous solubility.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:24661
Deposited By: Dr Bridgeen Callan
Deposited On:21 Jan 2013 12:39
Last Modified:17 Oct 2017 16:07

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