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Integrated transcriptome and proteome data: the challenges ahead.

Hack, Catherine Jane (2004) Integrated transcriptome and proteome data: the challenges ahead. Briefings in functional genomics & proteomics, 3 (3). pp. 212-9. [Journal article]

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The recent availability of platform technologies for high throughput proteome analysis has led to the emergence of integrated messenger RNA and protein expression data. The Pearson correlation coefficients for these data range from 0.46 to 0.76. In these integrated studies, serial analyses of gene expression and DNA microarrays have been used to quantify the transcriptome, while proteome analysis has been based on two-dimensional gel electrophoresis, isotope coded affinity tags and multidimensional protein identification technology. This paper provides a comprehensive review of the analytical techniques used in these studies and explores the extent to which the choice of experimental methodology can bias the correlation or the ability to detect proteins.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
ID Code:25740
Deposited By: Dr Catherine Hack
Deposited On:23 Apr 2013 09:48
Last Modified:23 Apr 2013 09:48

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