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Drug-Domain Interaction Networks in Myocardial Infarction

Wang, Haiying, Zheng, Huiru, Azuaje, Francisco and Zhao, Xing-Ming (2013) Drug-Domain Interaction Networks in Myocardial Infarction. IEEE Transactions on Nanobioscience, 12 (3). pp. 182-188. [Journal article]

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DOI: 10.1109/TNB.2013.2263556

Abstract

It has been well recognized that the pace of the development of new drugs and therapeutic interventions lags far behind biological knowledge discovery. Network-based approaches have emerged as a promising alternative to accelerate the discovery of new safe and effective drugs. Based on the integration of several biological resources including two recently published datasets i.e., Drug-target interactions in myocardial infarction (My-DTome) and drug-domain interaction network, this paper reports the association between drugs and protein domains in the context of myocardial infarction (MI). A MI drug-domain interaction network, My-DDome, was firstly constructed, followed by topological analysis and functional characterization of the network. The results show that My-DDome has a very clear modular structure, where drugs interacting with the same domain(s) within each module tend to have similar therapeutic effects. Moreover it has been found that drugs acting on blood and blood forming organs (ATC code B) and sensory organs (ATC code S) are significantly enriched in My-DDome $(p < 0.000001)$ , indicating that by incorporating protein domain information into My-DTome, more detailed insights into the interplay between drugs, their known targets, and seemingly unrelated proteins can be revealed.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Computing and Mathematics
Research Institutes and Groups:Computer Science Research Institute > Smart Environments
Computer Science Research Institute
Computer Science Research Institute > Artificial Intelligence and Applications
ID Code:26887
Deposited By: Dr Haiying Wang
Deposited On:13 Sep 2013 13:57
Last Modified:13 Sep 2013 13:57

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