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Antimicrobial activity of antihypertensive food-derived peptides and selected alanine analogues

McClean, Stephen, Beggs, Louise B and Welch, Rob (2014) Antimicrobial activity of antihypertensive food-derived peptides and selected alanine analogues. Food Chemistry, 146 . pp. 443-447. [Journal article]

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URL: http://www.sciencedirect.com/science/article/pii/S0308814613013599

DOI: 10.1016/j.foodchem.2013.09.094


This study evaluated four food-derived peptides with known antihypertensive activities for antimicrobial activity against pathogenic microorganisms, and assessed structure-function relationships using alanine analogues. The peptides (EVSLNSGYY, barley; PGTAVFK, soybean; TTMPLW, α-casein; VHLPP, α-zein) and the six alanine substitution peptides of PGTAVFK were synthesised, characterised and evaluated for antimicrobial activity using the bacteria, E. coli, S. aureus, and M. luteus and the yeast, C. albicans. The peptides TTMPLW and PGTAVFK inhibited growth of all four microorganisms tested, with activities of a similar order of magnitude to ampicillin and ethanol controls. EVSLNSGYY inhibited the growth of the bacteria, but VHLPP showed no antimicrobial activity. The alanine analogue, PGAAVFK showed the highest overall antimicrobial activity and PGTAVFA showed no activity; overall, the activities of the analogues were consistent with their structures. Some peptides with antihypertensive activity also show antimicrobial activity, suggesting that food-derived peptides may exert beneficia1 effects via a number of mechanisms.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:27278
Deposited By: Prof Stephen McClean
Deposited On:30 Sep 2013 09:15
Last Modified:19 Jun 2015 14:52

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