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Angiotensin II in the Elderly: Impact of Angiotensin II Type 1 Receptor Sensitivity on Peripheral Hemodynamics

Harris, Ryan, Wray, D Walter, Nishiyama, Steven and Richardson, Russell S (2008) Angiotensin II in the Elderly: Impact of Angiotensin II Type 1 Receptor Sensitivity on Peripheral Hemodynamics. Hypertension, 51 . pp. 1611-1616. [Journal article]

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DOI: 10.1161/HYPERTENSIONAHA.108.111294

Abstract

Exercise hyperemia is attenuated in the elderly, which may be attributed to local vasoregulatory pathways within the skeletal muscle vasculature. Therefore, we sought to determine whether healthy aging is associated with changes in angiotensin II (Ang II) receptor sensitivity through measurements of leg blood flow in resting and exercising skeletal muscle. In 12 (n6 young, 241 years; n6 older, 683 years) healthy volunteers, we determined changes in leg blood flow (ultrasound Doppler) before and during intra-arterial infusion of Ang II (0.8 ng/mL of leg blood flow per minute). Heart rate, arterial blood pressure, common femoral artery diameter, and mean blood velocity were measured at rest and during knee-extensor exercise at 20% and 40% of the maximal work rate (WRmax). At rest, Ang II infusion decreased leg blood flow to a greater extent in older (618%) subjects compared with younger subjects (315%). Compared with rest, Ang II–mediated vasoconstriction (leg blood flow) during exercise was diminished in both older and youngersubjects at 20% (older: 75%; younger: 212%) and 40% WRmax (older: 54%; younger: 93%). These data identify a clear age-related hypersensitivity to Ang II in the resting leg, which may contribute to the recognized decrement in leg blood flow in this cohort. However, the diminished vasoconstriction to Ang II during exercise suggests that the elevation in Ang II type 1 receptor sensitivity documented at rest does not contribute significantly to the blunted exercise hyperemia experienced with advancing age. (Hypertension. 2008;51:1611-1617.)

Item Type:Journal article
Keywords:basic science; elderly; blood flow regulation; exercise; angiotensin receptors
Faculties and Schools:Faculty of Life and Health Sciences > School of Sport
Faculty of Life and Health Sciences
Research Institutes and Groups:Sport and Exercise Sciences Research Institute
ID Code:27579
Deposited By: Mrs Julie Haydock
Deposited On:21 Oct 2013 08:49
Last Modified:09 Dec 2015 11:16

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