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Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis

Poore, Spencer, Berry, Breanna, Eidson, Dabney, McKie, Katie T and Harris, Ryan (2013) Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis. Chest, 143 (4). pp. 939-946. [Journal article]

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Abstract

Background: Cystic fibrosis (CF) is a genetic disorder that affects not only pulmonary function, but also multiple organ systems. The flow-mediated dilation (FMD) test is a non-invasive assessment of endothelial function and nitric oxide bioavailability. Thus, the purpose of this study was to determine if 1) endothelial dysfunction is present in young patients with CF, and 2) endothelial function is associated with pulmonary function and exercise capacity.Methods: 15 patients with CF and 15 demographically matched controls participated in this study. Spirometry, brachial artery FMD, and a maximal exercise capacity test on a cycle ergometer were performed on all subjects to determine pulmonary function, endothelial function, and exercise capacity, respectively.Results: No differences (p>0.05) in age, height, or BMI were observed between patients withCF and controls. FEV1 (% predicted), FEV1/FVC, and FEF25-75 were lower in patients with CF.VO2 peak (absolute and relative) was similar between groups; however, VO2 (% predicted andml/kg fat free mass/min) and peak workload were significantly (p<0.05) lower in patients withCF. FMD (4.9±2.6 vs. 7.5±3.1%; p=0.018) was lower in patients compared to controls, respectively. Relationships between FMD and both pulmonary function and exercise capacitywere identified.Conclusions: For the first time, these data provide evidence of vascular endothelial dysfunctionin a fairly healthy cohort of young patients with CF. In addition, our data demonstrates thecomplex relationships between endothelial function and both pulmonary function and exercisecapacity in young patients with CF.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Sport
Faculty of Life and Health Sciences
Research Institutes and Groups:Sport and Exercise Sciences Research Institute
ID Code:27581
Deposited By: Mrs Julie Haydock
Deposited On:21 Oct 2013 08:27
Last Modified:09 Dec 2015 11:16

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