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Biosensor Based on Ultrasmall MoS2 Nanoparticles for Electrochemical Detection of H2O2 Released by Cells at the Nanomolar Level

Wang, T, Zhu, H, Zhuo, J, Zhu, Z, Papakonstantinou, P, Lubarsky, G, Lin, J and Li, MX (2013) Biosensor Based on Ultrasmall MoS2 Nanoparticles for Electrochemical Detection of H2O2 Released by Cells at the Nanomolar Level. Analytical Chemistry, 85 . pp. 10289-10295. [Journal article]

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URL: http://pubs.acs.org/doi/abs/10.1021/ac402114c

DOI: dx.doi.org/10.1021/ac402114c

Abstract

Monodispersed surfactant-free MoS2 nanoparticles with sizes of less than2 nm were prepared from bulk MoS2 by simple ultrasonication and gradient centrifugation. The ultrasmall MoS2 nanoparticles expose a large fraction of edge sites, along with their high surface area, which lead to attractive electrocatalytic activity for reduction of H2O2. An extremely sensitive H2O2 biosensor based on MoS2 nanoparticles with a real determination limit as low as 2.5 nM and wide linear range of 5 orders of magnitude was constructed. On the basis of this biosensor, the trace amount of H2O2 released from Raw 264.7 cells was successfully recorded, and an efficient glucose biosensor was also fabricated. Since H2O2 is a byproduct of many oxidative biological reactions, this work serves as a pathway for the application of MoS2 in the fields of electrochemical sensing and bioanalysis.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:27923
Deposited By: Professor Pagona Papakonstantinou
Deposited On:12 Nov 2013 09:04
Last Modified:17 Oct 2017 16:12

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