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Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires

Maguire, PD, McLaughlin, JAD, Okpalugo, TIT, Lemoine, P, Papakonstantinou, P, McAdams, ET, Needham, M, Ogwu, AA, Ball, M and Abbas, GA (2005) Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires. DIAMOND AND RELATED MATERIALS, 14 (8). pp. 1277-1288. [Journal article]

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URL: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TWV-4FBM211-2-1&_cdi=5572&_user=126978&_orig=search&_coverDate=08%2F31%2F2005&_sk=999859991&view=c&wchp=dGLbVtz-zSkWA&md5=3a88dc0a70ee6e416b53beb4ca5c7994&ie=/sdarticle.pdf

DOI: 10.1016/j.diamond.2004.12.023


Diamond-ike carbon (DLC) coatings have been investigated with respect to biocompatibility, mechanical stability tinder biofluid exposure, corrosion resistance and the impact of the fabrication or operation of catheter guidewires and stents upon coating integrity. High mechanical tensile and compressive forces, during guidewire winding or stent expansion, pose severe limitations on the use of DLC-coated stainless steel. Doping with silicon and the use of an a-Si:H interlayer can help minimise the risk of adhesion failure or film cracking. The incorporation of Si increased the hydrogen content and the estimated sp(3) fraction but reduced the film hardness. Silicon-doped a-C:H coatings exhibit significantly improved corrosion barrier properties, with over two orders of magnitude increase in the charge transfer resistance. Immersion in biofluid, however, reduced the interfacial adhesion strength by up to 75%. Human microvascular endothelial cell attachment was enhanced while platelet attachment was reduced on Si-doped compared to undoped a-C:H. The macrophage response to nonhydrogenated tetragonal (t-aC) carbon show that these coatings stimulate less inflammatory activity than uncoated materials and produce comparable responses to already existing polyurethane coatings.(c) 2004 Published by Elsevier B.V.

Item Type:Journal article
Keywords:diamond-like carbon; biocompatibility; corrosion; stents
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:284
Deposited By: Mrs Ann Blair
Deposited On:19 Oct 2009 12:14
Last Modified:07 Apr 2014 13:50

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