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Longitudinal study of spherical refractive error in infantilenystagmus syndrome

Healey, Natasha, McClelland, Julie, Saunders, Kathryn and Jackson, Jonathan (2014) Longitudinal study of spherical refractive error in infantilenystagmus syndrome. Ophthalmic and Physiological Optics, 31 . [Journal article]

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DOI: 10.1111/opo.12117

Abstract

Purpose: To explore the onset and progression of spherical refractive error in a population with infantile nystagmus syndrome.Methods: Retrospective refractive error data were obtained from 147 medical records of children with infantile nystagmus syndrome (albinism n=98; idiopathic infantile nystagmus n=49), attending a low vision clinic in Northern Ireland, over a 24 year period (1986-2010). Data were categorised by age to allow for comparisons with published studies. A prospective group of participants with INS (n=22 [albinism n=18, idiopathic infantile nystagmus n=4]) (aged 0-4 years) were also recruited. Cycloplegic streak retinoscopy was performed biannually, over a three year period. Spherical equivalent refractive error and most ametropic meridian were analysed.Results: The mean spherical equivalent refractive errors for albinism and idiopathic infantile nystagmus groups (across all age categories) were hypermetropic, with highest levels demonstrated by the participants with albinism aged 1≤4 years (Mann-Whitney U test, p=0.013). Mean most ametropic meridian was highest in the albinism group aged 1≤12 years (Mann-Whitney U test, p<0.05). Individual data demonstrated relatively static spherical equivalent refractive errors over time. Prospective participants were hypermetropic at all visits and those with albinism had, on average, higher refractive errors than those with IIN. No significant correlations were noted between visual acuity and spherical equivalent refractive errors or most ametropic meridian. Conclusions: Hypermetropia is the most prevalent spherical refractive error in the INS population, irrespective of level of visual acuity. Individuals with infantile nystagmus syndrome fail to demonstrate typical patterns of emmetropisation, particularly in the presence of albinism.

Item Type:Journal article
Keywords:nystagmus, emmetropisation, vision, refractive error, children
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Vision
ID Code:28493
Deposited By: Dr Julie McClelland
Deposited On:28 Jan 2014 09:37
Last Modified:28 Jan 2014 09:37

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