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Assessment of Biochemical Liver Markers, Physical Activity, Fitness and Body Mass Index For a Cardiometabolic Risk Model in Childhood

Konidari, A, Auth, M K H, Murphy, MH, Cunningham, C, Foweather, L, Gobbi, R, Graves, L E F, Hopkins, N D, Stratton, G and Boddy, L M (2014) Assessment of Biochemical Liver Markers, Physical Activity, Fitness and Body Mass Index For a Cardiometabolic Risk Model in Childhood. Acta Paediatrica . [Journal article]

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DOI: 10.1111/apa.12591

Abstract

AimTo investigate clustered cardiometabolic risk scores in healthy 10 to 12-yearolds using anthropometric characteristics, measurements of cardiorespiratory fitness (CRF) and physical activity and blood markers of metabolic disease. We also evaluated how including markers of liver cell injury would affect the clustered cardiometabolic risk assessment model.MethodsThis cross-sectional study focused on 99 children aged 10 to 12 years. The main outcome included assessing participants with increased and low cardiometabolic risk factors using a clustered risk score model that incorporated markers implicated in metabolic syndrome pathogenesis. Two clustered risk scores were calculated, one incorporating markers of liver cell injury.ResultsChildren classified as ‘increased risk’ exhibited significantly lower CRF and higher body mass index Z-scores than their ‘low risk’ peers. No significant differences in physical activity were observed. This trend remained unchanged when markers of liver injury were included in the clustered risk assessment model.ConclusionThe clustered risk score model is a scientifically robust method of cardiometabolic risk assessment, which reiterates the importance of weight reduction and CRF promotion in childhood. Liver injury markers did not make a significant contribution to our study and further research is needed to evaluate their effect on cardiometabolic risk stratification in childhood.

Item Type:Journal article
Keywords:cardiorespiratory fitness, markers of liver cell injury, metabolic syndrome, obesity, physical activity
Faculties and Schools:Faculty of Life and Health Sciences > School of Sport
Faculty of Life and Health Sciences
Research Institutes and Groups:Sport and Exercise Sciences Research Institute
Sport and Exercise Sciences Research Institute > Centre for Physical Activity and Health
ID Code:28778
Deposited By: Mrs Julie Haydock
Deposited On:06 Mar 2014 13:39
Last Modified:16 Mar 2015 15:31

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