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In Vitro and in Vivo Models of Colorectal Cancer: Antigenotoxic Activity of Berries

Brown, Emma, Allsopp, Philip, Ternan, Nigel, McMullan, Geoffrey and Gill, Chris (2014) In Vitro and in Vivo Models of Colorectal Cancer: Antigenotoxic Activity of Berries. Journal of Agriculture and Food Chemistry, 76 (4). [Journal article]

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URL: http://pubs.acs.org/doi/abs/10.1021/jf4050759

DOI: 10.1021/jf4050759


The etiology of colorectal cancer (CRC), a common cause of cancer-related mortality globally, has strong associations with diet. There is considerable epidemiological evidence that fruits and vegetables are associated with reduced risk of CRC. This paper reviews the extensive evidence, both from in vitro studies and animal models, that components of berry fruits can modulate biomarkers of DNA damage and that these effects may be potentially chemoprotective, given the likely role that oxidative damage plays in mutation rate and cancer risk. Human intervention trials with berries are generally consistent in indicating a capacity to significantly decrease oxidative damage to DNA, but represent limited evidence for anticarcinogenicity, relying as they do on surrogate risk markers. To understand the effects of berry consumption on colorectal cancer risk, future studies will need to be well controlled, with defined berry extracts, using suitable and clinically relevant end points and considering the importance of the gut microbiota.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:28850
Deposited By: Dr Nigel Ternan
Deposited On:18 Mar 2014 10:59
Last Modified:18 Mar 2014 10:59

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