Abdel-Wahab, Yasser, Marenah, Lamin, Flatt, Peter and Conlon, J. Michael (2007) Insulin releasing properties of the temporin family of antimicrobial peptides. PROTEIN AND PEPTIDE LETTERS, 14 (7). pp. 702-707. [Journal article]
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Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10(-8) - 10(-6)M) produced significant (p<0.05) and concentration-dependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10(-8) - 10(-6)M) also stimulated insulin-release but were cytotoxic at 10(-6)M. Temporin-1DRa was without effect. The temporins at 10(-7) M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a K-ATP channel-independent pathway.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Diabetes
|Deposited By:||Professor Peter Flatt|
|Deposited On:||17 Dec 2009 15:02|
|Last Modified:||09 Jun 2010 10:18|
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