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From Single Cells to Tissues: Interactions between the Matrix and Human Breast Cells in Real Time

Barnes, Clifford, McKerr, George, Soto, A. M., Downes, Stephen, Howard, Vyvyan and Saetzler, Kurt (2014) From Single Cells to Tissues: Interactions between the Matrix and Human Breast Cells in Real Time. PLOS ONE, 9 (4). pp. 1-12. [Journal article]

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URL: http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0093325&representation=PDF

Abstract

Mammary gland morphogenesis involves ductal elongation, branching, and budding. All of these processes are mediated by stroma - epithelium interactions. Biomechanical factors, such as matrix stiffness, have been established as important factors in these interactions. For example, epithelial cells fail to form normal acinar structures in vitro in 3D gels that exceed the stiffness of a normal mammary gland. Additionally, heterogeneity in the spatial distribution of acini and ducts within individual collagen gels suggests that local organization of the matrix may guide morphogenesis. Here, we quantified the effects of both bulk material stiffness and local collagen fiber arrangement on epithelial morphogenesis.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Genomic Medicine
Biomedical Sciences Research Institute
ID Code:29205
Deposited By: Dr Clifford Barnes
Deposited On:09 Apr 2014 09:20
Last Modified:11 Feb 2016 17:20

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