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Programmed Self-Assembly of a Quadruplex DNA Nanowire

Ma’ani Hessari, N, Spindler, L, Troha, T, Lam, W.C, Drevenšek-Olenik, I and Webba da Silva, Mateus (2014) Programmed Self-Assembly of a Quadruplex DNA Nanowire. Chemistry - A European Journal, 20 . [Journal article]

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URL: http://onlinelibrary.wiley.com/doi/10.1002/chem.201300692/abstract

DOI: 10.1002/chem.201300692

Abstract

The ability to produce, reproducibly and systematically, well-defined quadruplex DNA nanowires through controlled rational design is poorly understood despite potential utility in structural nanotechnology. The programmed hierarchical self-assembly of a long four-stranded DNA nanowire through cohesive self-assembly of GpC and CpG “sticky” ends is reported. The encoding of bases within the quadruplex stem allows for an uninterrupted pi-stacking system with rectilinear propagation for hundreds of nanometers in length. The wire is mechanically stable and features superior nuclease resistance to double-stranded DNA. The study indicates the feasibility for programmed assembly of uninterrupted quadruplex DNA nanowires. This is fundamental to the systematic investigation of well-defined DNA nanostructures for uses in optoelectronic and electronic devices as well as other structural nanotechnology applications

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Genomic Medicine
Biomedical Sciences Research Institute
ID Code:30644
Deposited By: Dr Mateus Webba da Silva
Deposited On:05 Dec 2014 11:36
Last Modified:05 Dec 2014 11:36

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