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Phloroglucinols from Anti-Microbial Deposit-Resins of Australian Stingless Bees (Tetragonula carbonaria)

Massaro, C. Flavia, Smyth, Thomas J., Smyth, Franklin, Heard, Tim, Leonhardt, Sara D., Katouli, Mohammad, Wallace, Helen M. and Brooks, Peter (2014) Phloroglucinols from Anti-Microbial Deposit-Resins of Australian Stingless Bees (Tetragonula carbonaria). Phytotherapy Research, 29 (1). p. 48. [Journal article]

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URL: http://dx.doi.org/10.1002/ptr.5225

DOI: doi:10.1002/ptr.5225

Abstract

Stingless bees accumulate deposits of plant resins that are mixed with beeswax to produce propolis. Previous studies have reported anti-microbial constituents of stingless bee (Tetragonula carbonaria) propolis from East Australia, but several components remained to be characterized. In the search of natural products yet unreportedfor Australian propolis, four bee deposit-resins of T. carbonaria bees were analysed by gas and liquid chromatography mass spectrometry with accurate mass measurements. Ethanolic extracts of the deposit-resins were tested in vitro against Staphylococcus aureus ATCC 25983 and Pseudomonas aeruginosa ATCC 27853 by the agar diffusion method. Phloroglucinols, flavonoids and isoprenoids were identified in samples. The crudeextracts showed strong anti-staphylococcal effects but were less active against the Gram-negative bacterium. The diagnostic data enabled the identification of markers that can be used for profiling other Australian propolis sources and to target the isolation of bioactive phloroglucinols in future studies against antibiotic resistant S. aureus strains.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
ID Code:30955
Deposited By: Prof W.Franklin Smyth
Deposited On:09 Feb 2015 16:14
Last Modified:08 Nov 2017 10:04

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