Gibson, David S, Bustard, Michael, McGeough, Cathy, Murray, Helena A, Crockard, Martin A, McDowell, Andrew, Blayney, Jaine, Gardiner, Philip and Bjourson, AJ (2015) Current and future trends in biomarker discovery and development of companion diagnostics for arthritis. Expert Review of Molecular Diagnostics, 15 (2). pp. 219-234. [Journal article]
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Musculoskeletal diseases such as rheumatoid arthritis are complex multifactorial disorders which are chronic in nature and debilitating for patients. A number of drug families are available to clinicians to manage these disorders but few tests exist to target these to the most responsive patients. Therefore drug failure and switching to drugs with alternate modes of action is common place. In parallel, a limited number of laboratory tests are available which measure biological indicators or ‘biomarkers’ of disease activity, autoimmune status, or joint damage. There is a growing awareness that assimilating the fields of drug selection and diagnostic tests into ‘companion diagnostics’ could greatly advance disease management and improve outcomes for patients. This review aims to highlight: (i) the current applications of biomarkers in rheumatology with particular focus on companion diagnostics, (ii) developments in the fields of proteomics, genomics, the microbiome, imaging and bioinformatics, (iii) how integration of these technologies into clinical practice could support therapeutic decisions.
|Item Type:||Journal article|
|Keywords:||Rheumatoid Arthritis, companion diagnostic, proteomics, genomics, biomarker|
|Faculties and Schools:||Faculty of Life and Health Sciences > School of Biomedical Sciences|
Faculty of Life and Health Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Stratified Medicine
|Deposited By:||Dr David Gibson|
|Deposited On:||30 Jun 2015 08:21|
|Last Modified:||30 Jun 2015 08:21|
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Current and future trends in biomarker discovery and development of companion diagnostics for arthritis. (deposited 16 Dec 2014 09:38)
- Current and future trends in biomarker discovery and development of companion diagnostics for arthritis. (deposited 30 Jun 2015 08:21) [Currently Displayed]
- Current and future trends in biomarker discovery and development of companion diagnostics for arthritis. (deposited 01 Apr 2015 10:26)
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