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Current and future trends in biomarker discovery and development of companion diagnostics for arthritis

Gibson, David S, Bustard, Michael, McGeough, Cathy, Murray, Helena A, Crockard, Martin A, McDowell, Andrew, Blayney, Jaine, Gardiner, Philip and Bjourson, AJ (2015) Current and future trends in biomarker discovery and development of companion diagnostics for arthritis. Expert Review of Molecular Diagnostics, 15 (2). pp. 219-234. [Journal article]

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URL: http://informahealthcare.com/doi/abs/10.1586/14737159.2015.969244

DOI: 10.1586/14737159.2015.969244


Musculoskeletal diseases such as rheumatoid arthritis are complex multifactorial disorders which are chronic in nature and debilitating for patients. A number of drug families are available to clinicians to manage these disorders but few tests exist to target these to the most responsive patients. Therefore drug failure and switching to drugs with alternate modes of action is common place. In parallel, a limited number of laboratory tests are available which measure biological indicators or ‘biomarkers’ of disease activity, autoimmune status, or joint damage. There is a growing awareness that assimilating the fields of drug selection and diagnostic tests into ‘companion diagnostics’ could greatly advance disease management and improve outcomes for patients. This review aims to highlight: (i) the current applications of biomarkers in rheumatology with particular focus on companion diagnostics, (ii) developments in the fields of proteomics, genomics, the microbiome, imaging and bioinformatics, (iii) how integration of these technologies into clinical practice could support therapeutic decisions.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Stratified Medicine
ID Code:31277
Deposited By: Dr David Gibson
Deposited On:01 Apr 2015 10:26
Last Modified:01 Apr 2015 10:26

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