Barnett, CR, Abbott, RA, Bailey, CJ, Flatt, Peter and Ioannides, C (1992) CYTOCHROME-P450-DEPENDENT MIXED-FUNCTION OXIDASE AND GLUTATHIONE-S-TRANSFERASE ACTIVITIES IN SPONTANEOUS OBESITY-DIABETES. BIOCHEMICAL PHARMACOLOGY, 43 (8). pp. 1868-1871. [Journal article]
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The effect of non-insulin-dependent diabetes on the hepatic microsomal cytochrome P450-dependent mixed-function oxidase system and on cytosolic glutathione S-transferase activity was determined using the spontaneously obese-diabetic (ob/ob) mouse model. The activities of the xenobiotic-metabolizing cytochrome P450 proteins were monitored by the use of chemical probes. Non-insulin-dependent diabetes did not influence the hepatic metabolism of substrates associated with the P450 I, IIB. IIE. III and IV families of cytochromes. In contrast, cytosolic glutathione S-transferase activity was markedly reduced and glutathione levels were significantly lowered. These findings raise the possibility that patients suffering from this disease may be more susceptible to chemicals that rely on glutathione conjugation for their deactivation.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Diabetes
|Deposited By:||Professor Peter Flatt|
|Deposited On:||08 Jan 2010 11:59|
|Last Modified:||22 Jul 2011 13:18|
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