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Potential therapeutic applications of microbial surface-activecompounds

Fracchia, Letizia, Banat, Jareer J., Cavallo, Massimo, Ceresa, Chiara and Banat, Ibrahim (2015) Potential therapeutic applications of microbial surface-activecompounds. AIMS Bioengineering, 2 (3). pp. 144-162. [Journal article]

[img] Text - Published Version

DOI: doi: 10.3934/bioeng.2015.3.144


Numerous investigations of microbial surface-active compounds or biosurfactants over thepast two decades have led to the discovery of many interesting physicochemical and biologicalproperties including antimicrobial, anti-biofilm and therapeutic among many other pharmaceutical and medical applications. Microbial control and inhibition strategies involving the use of antibiotics are becoming continually challenged due to the emergence of resistant strains mostly embedded within biofilm formations that are difficult to eradicate. Different aspects of antimicrobial and anti-biofilm control are becoming issues of increasing importance in clinical, hygiene, therapeutic and other applications. Biosurfactants research has resulted in increasing interest into their ability to inhibit microbial activity and disperse microbial biofilms in addition to being mostly nontoxic and stable at extremes conditions. Some biosurfactants are now in use in clinical, food and environmental fields, whilst others remain under investigation and development. The dispersal properties of biosurfactants have been shown to rival that of conventional inhibitory agents against bacterial, fungal and yeast biofilms as well as viral membrane structures. This presents them as potential candidates for future uses in new generations of antimicrobial agents or as adjuvants to other antibiotics and use as preservatives for microbial suppression and eradication strategies.

Item Type:Journal article
Keywords:biosurfactants; biofilm; anti-biofilm; anti-adhesive; antimicrobial; adjuvants
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:32815
Deposited By: Professor Ibrahim Banat
Deposited On:28 Jan 2016 12:09
Last Modified:17 Oct 2017 16:20

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