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New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders.

Irwin, Nigel and Flatt, Peter (2015) New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders. World Journal of Diabetes, 6 (15). pp. 1285-1295. [Journal article]

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DOI: 10.4239/wjd.v6.i15.1285

Abstract

The applicability of stable gut hormones for the treatment of obesity-related diabetes is now undisputable. This is based predominantly on prominent and sustained glucose-lowering actions, plus evidence that these peptides can augment insulin secretion and pancreatic islet function over time. This review highlights the therapeutic potential of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), oxyntomodulin (OXM) and cholecystokinin (CCK) for obesity-related diabetes. Stable GLP-1 mimetics have already been successfully adopted into the diabetic clinic, whereas GIP, CCK and OXM molecules offer promise as potential new classes of antidiabetic drugs. Moreover, recent studies have shown improved therapeutic effects following simultaneous modulation of multiple receptor signalling pathways by combination therapy or use of dual/triple agonist peptides. However, timing and composition of injections may be important to permit interludes of beta-cell rest. The review also addresses the possible perils of incretin based drugs for treatment of prediabetes. Finally, the unanticipated utility of stable gut peptides as effective treatments for complications of diabetes, bone disorders, cognitive impairment and cardiovascular dysfunction is considered.

Item Type:Journal article
Keywords:Diabetes, Obesity, Incretin, Prediabetes, Gut hormones
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:32889
Deposited By: Dr Nigel Irwin
Deposited On:28 Jan 2016 12:09
Last Modified:28 Jan 2016 12:09

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