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Recent advances in amphiphilic polymers for simultaneous delivery of hydrophobic and hydrophilic drugs

Martin, Chloe, Aibani, Noorjahan, Callan, John and Callan, Bridgeen (2016) Recent advances in amphiphilic polymers for simultaneous delivery of hydrophobic and hydrophilic drugs. Therapeutic Delivery, 7 (1). pp. 15-31. [Journal article]

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DOI: 10.4155/tde.15.84

Abstract

Nanomedicine has evolved with the use of biological compounds such as proteins, peptides and DNA. These hydrophilic and often highly charged compounds require a delivery system to allow effective transport and release at the site of action. These new biological therapeutics have not replaced the more traditional smaller molecule, but instead are working synergistically to the benefit of the end user. To that end, drug delivery systems are now required to encapsulate both larger hydrophilic compounds as well as the smaller and generally more hydrophobic compound. This review highlights the emerging role in drug delivery of amphiphilic polymers that by theirvery nature can associate with compounds of differing physicochemical properties, inparticular the role of micelles, polymersomes and nanocapsules.

Item Type:Journal article
Keywords:Amphiphilic polymer, Polymeric micelle, Polymersome, Nanocapsule: Hydrophilic compounds, Hydrophobic compounds, Simultaneous drug delivery.
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:33008
Deposited By: Dr Bridgeen Callan
Deposited On:28 Jan 2016 12:09
Last Modified:05 Sep 2017 15:09

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