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Profile of refractive errors in European Caucasian children with Autistic Spectrum Disorder; increased prevalence and magnitude of astigmatism

Anketell, Pamela, Saunders, Kathryn, Gallagher, Stephen, Bailey, Claire and Little, Julie-Anne (2016) Profile of refractive errors in European Caucasian children with Autistic Spectrum Disorder; increased prevalence and magnitude of astigmatism. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 36 . [Journal article]

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DOI: 10.1111/opo.12286

Abstract

PurposeAutistic Spectrum Disorder (ASD) is a common neurodevelopmental disorder characterised by impairment of communication, social interaction and repetitive behaviours. Only a small number of studies have investigated fundamental clinical measures of vision including refractive error. The aim of this study was to describe the refractive profile of a population of children with ASD compared to typically developing (TD) children.MethodsRefractive error was assessed using the Shin-Nippon NVision-K 5001 open-field autorefractor following the instillation of cyclopentolate hydrochloride 1% eye drops.ResultsA total of 128 participants with ASD (mean age 10.9 ± 3.3 years) and 206 typically developing participants (11.5 ± 3.1 years) were recruited. There was no significant difference in median refractive error, either by spherical equivalent or most ametropic meridian between the ASD and TD groups (Spherical equivalent, Mann–Whitney U307 = 1.15, p = 0.25; Most Ametropic Meridian, U305 = 0.52, p = 0.60). Median refractive astigmatism was −0.50DC (range 0.00 to −3.50DC) for the ASD group and −0.50DC (Range 0.00 to −2.25DC) for the TD group. Magnitude and prevalence of refractive astigmatism (defined as astigmatism ≥1.00DC) was significantly greater in the ASD group compared to the typically developing group (ASD 26%, TD 8%, magnitude U305 = 3.86, p = 0.0001; prevalence (inline image , p < 0.0001).ConclusionsThis is the first study to describe the refractive profile of a population of European Caucasian children with ASD compared to a TD population of children. Unlike other neurodevelopmental conditions, there was no increased prevalence of spherical refractive errors in ASD but astigmatic errors were significantly greater in magnitude and prevalence. This highlights the need to examine refractive errors in this population.

Item Type:Journal article
Keywords:Autistic Spectrum Disorder; astigmatism; children; refractive error
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Biomedical Sciences Research Institute
Psychology Research Institute
Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute > Optometry and Vision Science
Psychology Research Institute > Behavioural Neuroscience and Behaviour Analysis
ID Code:33547
Deposited By: Dr Julie-Anne Little
Deposited On:08 Mar 2016 09:43
Last Modified:21 Sep 2017 12:49

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