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Potential use of the comet assay in the clinical management of cancer

McKenna, Declan, McKeown, Stephanie and McKelvey-Martin, Valerie J (2008) Potential use of the comet assay in the clinical management of cancer. Mutagenesis, 23 (3). pp. 183-190. [Journal article]

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URL: http://dx.doi.org/10.1093/mutage/gem054

DOI: doi:10.1093/mutage/gem054

Abstract

The comet assay has been widely used to measure a range of cellular responses to DNA damage and has found applications in genotoxicity studies, bio-monitoring, ecological testing and in the study of human disease. This review discusses how the comet assay has been applied to the study of DNA damage and repair associated with cancer. The potential of the assay as a tool for predicting an individual's tumour sensitivity to radiation and to various chemotherapeutic drugs is examined, as well as outlining the usefulness of the assay in assessing oxidative stress within tumours. In addition, we review the use of the comet assay in investigations of the DNA-damaging effect of anti-neoplastic drugs and radiation used during cancer therapy. The advantages and limitations of the comet assay in carrying out all these studies are outlined, and the suitability of the comet assay for use in the clinical management of cancer is discussed.

Item Type:Journal article
Keywords:Comet Assay, FISH-Comet, DNA Damage & repair
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Institute of Nursing and Health Research > Centre for Health and Rehabilitation Technologies
Biomedical Sciences Research Institute > Genomic Medicine
Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:33619
Deposited By: Dr Declan McKenna
Deposited On:15 Mar 2016 09:23
Last Modified:17 Oct 2017 16:21

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